Search Results
Overview
| Uniprot ID | V9HW90 |
|---|---|
| Protein Name | Glutathione reductase |
| Gene Name | HEL-75 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 97 | AAVVESHKLGGTCVN |
Function
Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol
Protein Sequence
10
MALLPRALSA
20
GAGPSWRRAA
30
RAFRGFLLLL
40
PEPAALTRAL
50
SRAMACRQEP
60
QPQGPPPAAG
70
AVASYDYLVI
80
GGGSGGLASA
90
RRAAELGARA
100
AVVESHKLGG
110
TCVNVGCVPK
120
KVMWNTAVHS
130
EFMHDHADYG
140
FPSCEGKFNW
150
RVIKEKRDAY
160
VSRLNAIYQN
170
NLTKSHIEII
180
RGHAAFTSDP
190
KPTIEVSGKK
200
YTAPHILIAT
210
GGMPSTPHES
220
QIPGASLGIT
230
SDGFFQLEEL
240
PGRSVIVGAG
250
YIAVEMAGIL
260
SALGSKTSLM
270
IRHDKVLRSF
280
DSMISTNCTE
290
ELENAGVEVL
300
KFSQVKEVKK
310
TLSGLEVSMV
320
TAVPGRLPVM
330
TMIPDVDCLL
340
WAIGRVPNTK
350
DLSLNKLGIQ
360
TDDKGHIIVD
370
EFQNTNVKGI
380
YAVGDVCGKA
390
LLTPVAIAAG
400
RKLAHRLFEY
410
KEDSKLDYNN
420
IPTVVFSHPP
430
IGTVGLTEDE
440
AIHKYGIENV
450
KTYSTSFTPM
460
YHAVTKRKTK
470
CVMKMVCANK
480
EEKVVGIHMQ
490
GLGCDEMLQG
500
FAVAVKMGAT
510
KADFDNTVAI
520
HPTSSEELVT
LR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0004362 | glutathione-disulfide reductase (NADPH) activity |
| Molecular Function | GO:0050661 | NADP binding |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0006749 | glutathione metabolic process |
Reference
PMID: N/A