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Overview

Uniprot IDV9HWB8
Protein NamePyruvate kinase
Gene NameHEL-S-30
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
151 LDNAYMEKCDENILW
322 GRCNRAGKPVICATQ
367 MLSGETAKGDYPLEA
475 GIFPVLCKDPVQEAW

Function

Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival

Protein Sequence

10 MSKPHSEAGT 20 AFIQTQQLHA 30 AMADTFLEHM 40 CRLDIDSPPI 50 TARNTGIICT 60 IGPASRSVET 70 LKEMIKSGMN 80 VARLNFSHGT 90 HEYHAETIKN 100 VRTATESFAS 110 DPILYRPVAV 120 ALDTKGPEIR 130 TGLIKGSGTA 140 EVELKKGATL 150 KITLDNAYME 160 KCDENILWLD 170 YKNICKVVEV 180 GSKIYVDDGL 190 ISLQVKQKGA 200 DFLVTEVENG 210 GSLGSKKGVN 220 LPGAAVDLPA 230 VSEKDIQDLK 240 FGVEQDVDMV 250 FASFIRKASD 260 VHEVRKVLGE 270 KGKNIKIISK 280 IENHEGVRRF 290 DEILEASDGI 300 MVARGDLGIE 310 IPAEKVFLAQ 320 KMMIGRCNRA 330 GKPVICATQM 340 LESMIKKPRP 350 TRAEGSDVAN 360 AVLDGADCIM 370 LSGETAKGDY 380 PLEAVRMQHL 390 IAREAEAAIY 400 HLQLFEELRR 410 LAPITSDPTE 420 ATAVGAVEAS 430 FKCCSGAIIV 440 LTKSGRSAHQ 450 VARYRPRAPI 460 IAVTRNPQTA 470 RQAHLYRGIF 480 PVLCKDPVQE 490 AWAEDVDLRV 500 NFAMNVGKAR 510 GFFKKGDVVI 520 VLTGWRPGSG 530 FTNTMRVVPV P

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005929 cilium
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005791 rough endoplasmic reticulum
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016301 kinase activity
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0030955 potassium ion binding
Molecular Function GO:0004743 pyruvate kinase activity
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:2000767 positive regulation of cytoplasmic translation

Reference

PMID: N/A