Search Results
Overview
| Uniprot ID | V9HWE9 |
|---|---|
| Protein Name | Glutathione S-transferase |
| Gene Name | HEL-S-22 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | GVEDLRCKYISLIYT |
| 30 | ADQGQSWKEEVVTVE |
| 45 | TWQEGSLKASCLYGQ |
Function
Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration
Protein Sequence
10
MPPYTVVYFP
20
VRGRCAALRM
30
LLADQGQSWK
40
EEVVTVETWQ
50
EGSLKASCLY
60
GQLPKFQDGD
70
LTLYQSNTIL
80
RHLGRTLGLY
90
GKDQQEAALV
100
DMVNDGVEDL
110
RCKYISLIYT
120
NYEAGKDDYV
130
KALPGQLKPF
140
ETLLSQNQGG
150
KTFIVGDQIS
160
FADYNLLDLL
170
LIHEVLAPGC
180
LDAFPLLSAY
190
VGRLSARPKL
200
KAFLASPEYV
210
NLPINGNGKQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0015643 | toxic substance binding |
| Biological Process | GO:0031100 | animal organ regeneration |
| Biological Process | GO:0071460 | cellular response to cell-matrix adhesion |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0071385 | cellular response to glucocorticoid stimulus |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0071672 | negative regulation of smooth muscle cell chemotaxis |
| Biological Process | GO:1904706 | negative regulation of vascular associated smooth muscle cell proliferation |
| Biological Process | GO:0014003 | oligodendrocyte development |
| Biological Process | GO:0043200 | response to amino acid |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0033591 | response to L-ascorbic acid |
| Biological Process | GO:0009636 | response to toxic substance |
Reference
PMID: N/A