Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats
PMID: 36030297
DOI: 10.1007/s10571-022-01277-6
Authors: Yao Y, Bade R, Li G, Zhang A, Zhao H et al
Journal: Cellular and molecular neurobiology (2023)
36030297_rattus_norvegicus — Rattus norvegicus
| Tissue or cell | Rat cerebral cortex/cerebral endothelial tissue |
|---|---|
| Condition | Cerebral ischemia-reperfusion injury versus healthy control |
| Enrichment method | Pan anti-Kla antibody enrichment |
| MS instrument | Q Exactive Plus |
| Search software | MaxQuant |
| Localization threshold | A localization-probability threshold was used; exact value Not reported |
| FDR | FDR <1% |
| Source-reported sites / proteins | 1003 / 469 |
| KlaDB-retained sites / proteins | 733 / 342 |
| Evidence source | 10 local files; primary article/source file: 10571_2022_Article_1277.pdf |
| Curation notes | The current KlaDB count is lower than the source report. Record losses from UniProt mapping, residue validation, filtering, and within-study deduplication.; Repository/accession: PXD034232, iProX; Additional criterion: Quantifiable subset: 660 sites on 310 proteins |