Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma
PMID: 36625413
DOI: 10.1002/pmic.202200432
Authors: Hong H, Chen X, Wang H, Gu X, Yuan Y et al
Journal: Proteomics (2023)
36625413_homo_sapiens — Homo sapiens
| Tissue or cell | Non-metastatic HCC, normal liver, and HCC lung-metastasis tissues |
|---|---|
| Condition | Three-group comparison |
| Enrichment method | Pan anti-Kla antibody affinity enrichment |
| MS instrument | Q Exactive HF-X |
| Search software | MaxQuant |
| Localization threshold | A site-localization threshold was applied; exact value Not reported |
| FDR | Approximately 1%; exact value Not reported |
| Source-reported sites / proteins | 2045 / 960 |
| KlaDB-retained sites / proteins | 2033 / 951 |
| Evidence source | 8 local files; primary article/source file: Proteomics - 2023 - Hong - Global profiling of protein lysine lactylation and potential target modified protein analysis in.pdf |
| Curation notes | Counts are approximately consistent. Site-level provenance should still be represented through normalized Study and SiteEvidence records.; Repository/accession: PXD037371; Additional criterion: Quantifiable subset: 1,438 sites on 772 proteins |