Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy
PMID: 37159428
DOI: 10.1021/acs.jproteome.2c00756
Authors: Lin Y, Chen M, Wang D, Yu Y, Chen R et al
Journal: Journal of proteome research (2023)
37159428_homo_sapiens — Homo sapiens
| Tissue or cell | Pathological rotator-cuff tendon and normal control tendon |
|---|---|
| Condition | Rotator cuff tendinopathy versus normal control |
| Enrichment method | Affinity enrichment of lactylated peptides |
| MS instrument | Q Exactive HF-X |
| Search software | MaxQuant |
| Localization threshold | Not reported |
| FDR | Approximately 1%; exact value Not reported |
| Source-reported sites / proteins | 872 / 284 |
| KlaDB-retained sites / proteins | 1255 / 448 |
| Evidence source | 6 local files; primary article/source file: pr2c00756.pdf |
| Curation notes | The current database-linked count exceeds the source report. Investigate PMID propagation across merged sites and rebuild normalized site-level evidence links.; Repository/accession: PXD033146; Additional criterion: Upregulated: 136 sites/77 proteins; downregulated: 56 sites/32 proteins |