Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients
PMID: 40112136
DOI: 10.1021/acs.jproteome.4c00680
Authors: Hu J, Jin Z, Gao Y, Liu Q, Yu Y et al
Journal: Journal of proteome research (2025)
40112136_homo_sapiens — Homo sapiens
| Tissue or cell | Synovial tissue from rheumatoid arthritis and osteoarthritis patients |
|---|---|
| Condition | Rheumatoid arthritis versus osteoarthritis |
| Enrichment method | Affinity enrichment of lactylated peptides |
| MS instrument | LC-MS/MS; instrument model Not reported |
| Search software | Not reported |
| Localization threshold | Not reported |
| FDR | Not reported |
| Source-reported sites / proteins | Not reported / Not reported |
| KlaDB-retained sites / proteins | 25 / 18 |
| Evidence source | 2 local files; primary article/source file: pr4c00680.pdf |
| Curation notes | The original global site total was not available in the current metadata. The value was Not reported in the available source materials.; Repository/accession: PXD059145; Additional criterion: RA: 566 sites/250 proteins; OA: 548 sites/220 proteins; four sites validated by immunoprecipitation |