Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells
PMID: 40590393
DOI: 10.1021/acschembio.5c00270
Authors: Guo X, Ren X, Yan C, Huang H
Journal: ACS chemical biology (2025)
40590393_homo_sapiens — Homo sapiens
| Tissue or cell | Lenalidomide-sensitive and lenalidomide-resistant multiple-myeloma cells |
|---|---|
| Condition | Lenalidomide-sensitive versus resistant cells |
| Enrichment method | Affinity enrichment of lactylated peptides; antibody details Not reported |
| MS instrument | Q Exactive HF-X |
| Search software | MaxQuant 2.x |
| Localization threshold | Not reported |
| FDR | Peptide and protein FDR 1% |
| Source-reported sites / proteins | 1241 / Not reported |
| KlaDB-retained sites / proteins | 1220 / 673 |
| Evidence source | 5 local files; primary article/source file: cb5c00270.pdf |
| Curation notes | The current KlaDB count is lower than the source report. Record losses from UniProt mapping, residue validation, filtering, and within-study deduplication.; Repository/accession: PXD049794; Additional criterion: 7,493 total proteins and 1,241 Kla sites; Kla-protein total Not reported |