Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell
PMID: 40634431
DOI: 10.1038/s41598-025-09937-5
Authors: He J, Lai T, Zhou Z, Yang H, Lei Z et al
Journal: Scientific reports (2025)
40634431_homo_sapiens — Homo sapiens
| Tissue or cell | A549 lung adenocarcinoma cells |
|---|---|
| Condition | Joint profiling of acylation modifications; subsequent radioresistance/NHEJ analyses |
| Enrichment method | Antibody-conjugated agarose enrichment of lactylated peptides |
| MS instrument | LC-MS/MS; instrument model Not reported |
| Search software | Not reported |
| Localization threshold | Not reported |
| FDR | Not reported |
| Source-reported sites / proteins | 3110 / 1220 |
| KlaDB-retained sites / proteins | 3095 / 1215 |
| Evidence source | 7 local files; primary article/source file: 41598_2025_Article_9937.pdf |
| Curation notes | Counts are approximately consistent. Site-level provenance should still be represented through normalized Study and SiteEvidence records.; Additional criterion: Kla, Kcr, Ksu, and phosphorylation were profiled; this table records Kla only |