Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia
PMID: 40963935
DOI: 10.3389/fneur.2025.1629474
Authors: Chen Y, Sun W, Sun Z, Zhao H, Wu T et al
Journal: Frontiers in neurology (2025)
40963935_rattus_norvegicus — Rattus norvegicus
| Tissue or cell | Rat hippocampal tissue |
|---|---|
| Condition | Sham, four-vessel occlusion vascular-dementia model, and 21-day electroacupuncture treatment |
| Enrichment method | Anti-lactyllysine antibody (PTM-1401RM) enrichment |
| MS instrument | timsTOF Pro |
| Search software | Spectronaut 17 |
| Localization threshold | Not reported |
| FDR | Precursor and protein FDR 1% |
| Source-reported sites / proteins | 8852 / 2786 |
| KlaDB-retained sites / proteins | 6778 / 2184 |
| Evidence source | 7 local files; primary article/source file: fneur-16-1629474.pdf |
| Curation notes | The current KlaDB count is lower than the source report. Record losses from UniProt mapping, residue validation, filtering, and within-study deduplication.; Additional criterion: Differential results are reported for 4-VO versus sham and electroacupuncture versus 4-VO |