Characterization of protein lactylation in healthy and ischemic mouse hearts
PMID: 41089239
DOI: 10.3389/fcvm.2025.1644886
Authors: Wu D, Tang Y, Li X, Xiong S, Zhang Z et al
Journal: Frontiers in cardiovascular medicine (2025)
41089239_mus_musculus — Mus musculus
| Tissue or cell | Mouse heart tissue |
|---|---|
| Condition | Healthy control versus myocardial infarction, 3 days after induction |
| Enrichment method | Immunoaffinity enrichment of lactylated peptides |
| MS instrument | timsTOF Pro |
| Search software | Spectronaut 17 |
| Localization threshold | Not reported |
| FDR | Precursor and protein FDR 1% |
| Source-reported sites / proteins | 1674 / 477 |
| KlaDB-retained sites / proteins | 1671 / 475 |
| Evidence source | 9 local files; primary article/source file: 41089239.pdf |
| Curation notes | Counts are approximately consistent. Site-level provenance should still be represented through normalized Study and SiteEvidence records.; Additional criterion: MI comparison: 61 sites/53 proteins upregulated and 30 sites/27 proteins downregulated |