Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia
PMID: 41192556
DOI: 10.1016/j.mcpro.2025.101439
Authors: Yan M, Tu H, Tang S, Gai Z, Shi Q et al
Journal: Molecular & cellular proteomics : MCP (2025)
41192556_homo_sapiens — Homo sapiens
| Tissue or cell | Sperm from men with asthenozoospermia and normozoospermic controls |
|---|---|
| Condition | Asthenozoospermia versus normal sperm |
| Enrichment method | Anti-L-lactyllysine antibody enrichment |
| MS instrument | Orbitrap Fusion Lumos |
| Search software | Spectronaut |
| Localization threshold | Low-localization-probability sites were removed; exact threshold Not reported |
| FDR | Modification-site, peptide, and protein FDR approximately 1% |
| Source-reported sites / proteins | Not reported / 220 |
| KlaDB-retained sites / proteins | 557 / 231 |
| Evidence source | 9 local files; primary article/source file: main.pdf |
| Curation notes | The historical nine-digit identifier was normalized to PMID 41192556.; Repository/accession: PXD064912; Additional criterion: The abstract reports 220 lactylated proteins; the total site count was Not reported |