Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer
PMID: 41566505
DOI: 10.1186/s12957-026-04201-0
Authors: Chao L, Xu Y, Yang Y, Ao X, Liang J
Journal: World journal of surgical oncology (2026)
41566505_homo_sapiens — Homo sapiens
| Tissue or cell | Triple-negative breast-cancer tissues/cohorts and cell models |
|---|---|
| Condition | TNBC molecular analyses and PGK1 perturbation lactylomics |
| Enrichment method | Anti-lactyllysine antibody enrichment |
| MS instrument | timsTOF HT |
| Search software | Not reported |
| Localization threshold | Not reported |
| FDR | Protein and peptide FDR <1% |
| Source-reported sites / proteins | Not reported / 227 |
| KlaDB-retained sites / proteins | 279 / 227 |
| Evidence source | 4 local files; primary article/source file: 12957_2026_Article_4201.pdf |
| Curation notes | The original global site total was not available in the current metadata. The value was Not reported in the available source materials.; Additional criterion: 227 proteins showed altered lactylation downstream of PGK1; site total Not reported |